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Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu(5)
A high-throughput cell-based screen identified a series of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of metabotropic glutamate receptor 5 (mGlu(5)). This communication describes the SAR of this series and the profile of selected compounds in selectivity and radioligand bindi...
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| Main Authors: | , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2801349/ https://ncbi.nlm.nih.gov/pubmed/19854049 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.10.024 |
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