Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu(5)

A high-throughput cell-based screen identified a series of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of metabotropic glutamate receptor 5 (mGlu(5)). This communication describes the SAR of this series and the profile of selected compounds in selectivity and radioligand bindi...

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Detalhes bibliográficos
Main Authors: Felts, Andrew S., Saleh, Sam A., Le, Uyen, Rodriguez, Alice L., Weaver, C. David, Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801349/
https://ncbi.nlm.nih.gov/pubmed/19854049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.10.024
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