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A Bridging Interaction Allows Calmodulin to Activate NO Synthase through a Bi-modal Mechanism

Calmodulin (CaM) activates the nitric-oxide synthases (NOS) by a mechanism that is not completely understood. A recent crystal structure showed that bound CaM engages in a bridging interaction with the NOS FMN subdomain. We investigated its importance in neuronal NOS (nNOS) by mutating the two resid...

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מידע ביבליוגרפי
Main Authors: Tejero, Jesús, Haque, Mohammad Mahfuzul, Durra, Deborah, Stuehr, Dennis J.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2010
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923985/
https://ncbi.nlm.nih.gov/pubmed/20529840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.126797
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