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A Bridging Interaction Allows Calmodulin to Activate NO Synthase through a Bi-modal Mechanism
Calmodulin (CaM) activates the nitric-oxide synthases (NOS) by a mechanism that is not completely understood. A recent crystal structure showed that bound CaM engages in a bridging interaction with the NOS FMN subdomain. We investigated its importance in neuronal NOS (nNOS) by mutating the two resid...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2923985/ https://ncbi.nlm.nih.gov/pubmed/20529840 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.126797 |
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