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Tyrosine nitration on calmodulin enhances calcium-dependent association and activation of nitric-oxide synthase

Production of reactive oxygen species caused by dysregulated endothelial nitric-oxide synthase (eNOS) activity is linked to vascular dysfunction. eNOS is a major target protein of the primary calcium-sensing protein calmodulin. Calmodulin is often modified by the main biomarker of nitroxidative stre...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Porter, Joseph J., Jang, Hyo Sang, Haque, Mohammad Mahfuzul, Stuehr, Dennis J., Mehl, Ryan A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7039552/
https://ncbi.nlm.nih.gov/pubmed/31914408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010999
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