Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors

Haspin is a serine/threonine kinase required for completion of normal mitosis that is highly expressed during cell proliferation, including in a number of neoplasms. Consequently, it has emerged as a potential therapeutic target in oncology. A high throughput screen of approximately 140,000 compound...

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Detalhes bibliográficos
Main Authors: Cuny, Gregory D., Robin, Maxime, Ulyanova, Natalia P., Patnaik, Debasis, Pique, Valerie, Casano, Gilles, Liu, Ji-Feng, Lin, Xiangjie, Xian, Jun, Glicksman, Marcie A., Stein, Ross L., Higgins, Jonathan M.G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923816/
https://ncbi.nlm.nih.gov/pubmed/20529681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.04.150
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