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Antagonistic role of hnRNP A1 and KSRP in the regulation of Let-7a biogenesis
The pluripotency promoting proteins Lin28a and Lin28b act as posttranscriptional repressors of let-7 miRNA biogenesis in undifferentiated embryonic stem cells. The levels of mature let-7a differ substantially in cells lacking Lin28 expression, indicating the existence of additional mechanism(s) of p...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2923024/ https://ncbi.nlm.nih.gov/pubmed/20639884 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1874 |
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