Selection of Alternative 5′ Splice Sites: Role of U1 snRNP and Models for the Antagonistic Effects of SF2/ASF and hnRNP A1

The first component known to recognize and discriminate among potential 5′ splice sites (5′SSs) in pre-mRNA is the U1 snRNP. However, the relative levels of U1 snRNP binding to alternative 5′SSs do not necessarily determine the splicing outcome. Strikingly, SF2/ASF, one of the essential SR protein-s...

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Detalhes bibliográficos
Main Authors: Eperon, Ian C., Makarova, Olga V., Mayeda, Akila, Munroe, Stephen H., Cáceres, Javier F., Hayward, Daniel G., Krainer, Adrian R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
Assuntos:
Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC102138/
https://ncbi.nlm.nih.gov/pubmed/11046128
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