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Identification of Small Molecule Inhibitors of Clostridium perfringens ε-Toxin Cytotoxicity Using a Cell-Based High-Throughput Screen

The Clostridium perfringens epsilon toxin, a select agent, is responsible for a severe, often fatal enterotoxemia characterized by edema in the heart, lungs, kidney, and brain. The toxin is believed to be an oligomeric pore-forming toxin. Currently, there is no effective therapy for countering the c...

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Bibliografiske detaljer
Main Authors: Lewis, Michelle, Weaver, Charles David, McClain, Mark S.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922765/
https://ncbi.nlm.nih.gov/pubmed/20721308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins2071825
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