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D-peptide inhibitors of the p53–MDM2 interaction for targeted molecular therapy of malignant neoplasms
The oncoproteins MDM2 and MDMX negatively regulate the activity and stability of the tumor suppressor protein p53, conferring tumor development and survival. Antagonists targeting the p53-binding domains of MDM2 and MDMX kill tumor cells both in vitro and in vivo by reactivating the p53 pathway, pro...
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| 主要な著者: | , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2922601/ https://ncbi.nlm.nih.gov/pubmed/20660730 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1008930107 |
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