D-peptide inhibitors of the p53–MDM2 interaction for targeted molecular therapy of malignant neoplasms

The oncoproteins MDM2 and MDMX negatively regulate the activity and stability of the tumor suppressor protein p53, conferring tumor development and survival. Antagonists targeting the p53-binding domains of MDM2 and MDMX kill tumor cells both in vitro and in vivo by reactivating the p53 pathway, pro...

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Autori principali: Liu, Min, Li, Chong, Pazgier, Marzena, Li, Changqing, Mao, Yubin, Lv, Yifan, Gu, Bing, Wei, Gang, Yuan, Weirong, Zhan, Changyou, Lu, Wei-Yue, Lu, Wuyuan
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2010
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922601/
https://ncbi.nlm.nih.gov/pubmed/20660730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1008930107
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