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Fourier analysis and systems identification of the p53 feedback loop
A key circuit in the response of cells to damage is the p53–mdm2 feedback loop. This circuit shows sustained, noisy oscillations in individual human cells following DNA breaks. Here, we apply an engineering approach known as systems identification to quantify the in vivo interactions in the circuit...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2922141/ https://ncbi.nlm.nih.gov/pubmed/20622152 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1001107107 |
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