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Fourier analysis and systems identification of the p53 feedback loop

A key circuit in the response of cells to damage is the p53–mdm2 feedback loop. This circuit shows sustained, noisy oscillations in individual human cells following DNA breaks. Here, we apply an engineering approach known as systems identification to quantify the in vivo interactions in the circuit...

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書誌詳細
主要な著者: Geva-Zatorsky, Naama, Dekel, Erez, Batchelor, Eric, Lahav, Galit, Alon, Uri
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922141/
https://ncbi.nlm.nih.gov/pubmed/20622152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1001107107
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