The Disintegrin/Metalloproteinase ADAM10 Is Essential for the Establishment of the Brain Cortex

The metalloproteinase and major amyloid precursor protein (APP) α-secretase candidate ADAM10 is responsible for the shedding of proteins important for brain development, such as cadherins, ephrins, and Notch receptors. Adam10 (−/−) mice die at embryonic day 9.5, due to major defects in development o...

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Main Authors: Jorissen, Ellen, Prox, Johannes, Bernreuther, Christian, Weber, Silvio, Schwanbeck, Ralf, Serneels, Lutgarde, Snellinx, An, Craessaerts, Katleen, Thathiah, Amantha, Tesseur, Ina, Bartsch, Udo, Weskamp, Gisela, Blobel, Carl P., Glatzel, Markus, De Strooper, Bart, Saftig, Paul
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2010
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2921981/
https://ncbi.nlm.nih.gov/pubmed/20371803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5221-09.2010
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