Chemomechanical Regulation of SNARE Proteins Studied with Molecular Dynamics Simulations

SNAP-25B is a neuronal protein required for neurotransmitter (NT) release and is the target of Botulinum Toxins A and E. It has two SNARE domains that form a four-helix bundle when combined with syntaxin 1A and synaptobrevin. Formation of the three-protein complex requires both SNARE domains of SNAP...

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Hlavní autoři: Bock, Lars V., Hutchings, Brian, Grubmüller, Helmut, Woodbury, Dixon J.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2010
Témata:
Protein
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920728/
https://ncbi.nlm.nih.gov/pubmed/20713006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.06.019
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