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Agmatine reduces extracellular glutamate during pentylenetetrazole-induced seizures in rat brain: A potential mechanism for the anticonvulsive effects

Glutamate has been implicated in the initiation and spread of seizure activity. Agmatine, an endogenous neuromodulator, is an antagonist of NMDA receptors and has anticonvulsive effects. Whether agmatine regulate glutamate release, as measured by in vivo microdialysis, is not known. In this study, w...

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Autors principals: Feng, Yangzheng, LeBlanc, Michael H., Regunathan, Soundar
Format: Artigo
Idioma:Inglês
Publicat: 2005
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920494/
https://ncbi.nlm.nih.gov/pubmed/16125317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2005.08.008
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