Extranuclear estrogen receptor-α stimulates NeuroD1 binding to the insulin promoter and favors insulin synthesis

Estrogen receptors (ERs) protect pancreatic islet survival in mice through rapid extranuclear actions. ERα also enhances insulin synthesis in cultured islets. Whether ERα stimulates insulin synthesis in vivo and, if so, through which mechanism(s) remain largely unknown. To address these issues, we g...

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Detaylı Bibliyografya
Asıl Yazarlar: Wong, Winifred P. S., Tiano, Joseph P., Liu, Suhuan, Hewitt, Sylvia C., Le May, Cedric, Dalle, Stéphane, Katzenellenbogen, John A., Katzenellenbogen, Benita S., Korach, Kenneth S., Mauvais-Jarvis, Franck
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2010
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919966/
https://ncbi.nlm.nih.gov/pubmed/20616010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914501107
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