Extranuclear estrogen receptor-α stimulates NeuroD1 binding to the insulin promoter and favors insulin synthesis

Estrogen receptors (ERs) protect pancreatic islet survival in mice through rapid extranuclear actions. ERα also enhances insulin synthesis in cultured islets. Whether ERα stimulates insulin synthesis in vivo and, if so, through which mechanism(s) remain largely unknown. To address these issues, we g...

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Hauptverfasser: Wong, Winifred P. S., Tiano, Joseph P., Liu, Suhuan, Hewitt, Sylvia C., Le May, Cedric, Dalle, Stéphane, Katzenellenbogen, John A., Katzenellenbogen, Benita S., Korach, Kenneth S., Mauvais-Jarvis, Franck
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2010
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919966/
https://ncbi.nlm.nih.gov/pubmed/20616010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914501107
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