Extranuclear estrogen receptor-α stimulates NeuroD1 binding to the insulin promoter and favors insulin synthesis

Estrogen receptors (ERs) protect pancreatic islet survival in mice through rapid extranuclear actions. ERα also enhances insulin synthesis in cultured islets. Whether ERα stimulates insulin synthesis in vivo and, if so, through which mechanism(s) remain largely unknown. To address these issues, we g...

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Detalhes bibliográficos
Main Authors: Wong, Winifred P. S., Tiano, Joseph P., Liu, Suhuan, Hewitt, Sylvia C., Le May, Cedric, Dalle, Stéphane, Katzenellenbogen, John A., Katzenellenbogen, Benita S., Korach, Kenneth S., Mauvais-Jarvis, Franck
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919966/
https://ncbi.nlm.nih.gov/pubmed/20616010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914501107
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