Extranuclear estrogen receptor-α stimulates NeuroD1 binding to the insulin promoter and favors insulin synthesis

Estrogen receptors (ERs) protect pancreatic islet survival in mice through rapid extranuclear actions. ERα also enhances insulin synthesis in cultured islets. Whether ERα stimulates insulin synthesis in vivo and, if so, through which mechanism(s) remain largely unknown. To address these issues, we g...

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Autori principali: Wong, Winifred P. S., Tiano, Joseph P., Liu, Suhuan, Hewitt, Sylvia C., Le May, Cedric, Dalle, Stéphane, Katzenellenbogen, John A., Katzenellenbogen, Benita S., Korach, Kenneth S., Mauvais-Jarvis, Franck
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2010
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919966/
https://ncbi.nlm.nih.gov/pubmed/20616010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914501107
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