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Importance of Extranuclear Estrogen Receptor-α and Membrane G Protein–Coupled Estrogen Receptor in Pancreatic Islet Survival
OBJECTIVE: We showed that 17β-estradiol (E(2)) favors pancreatic β-cell survival via the estrogen receptor-α (ERα) in mice. E(2) activates nuclear estrogen receptors via an estrogen response element (ERE). E(2) also activates nongenomic signals via an extranuclear form of ERα and the G protein–coupl...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Diabetes Association
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2750222/ https://ncbi.nlm.nih.gov/pubmed/19587358 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-0257 |
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