Importance of Extranuclear Estrogen Receptor-α and Membrane G Protein–Coupled Estrogen Receptor in Pancreatic Islet Survival

OBJECTIVE: We showed that 17β-estradiol (E(2)) favors pancreatic β-cell survival via the estrogen receptor-α (ERα) in mice. E(2) activates nuclear estrogen receptors via an estrogen response element (ERE). E(2) also activates nongenomic signals via an extranuclear form of ERα and the G protein–coupl...

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Autors principals: Liu, Suhuan, Le May, Cedric, Wong, Winifred P.S., Ward, Robert D., Clegg, Deborah J., Marcelli, Marco, Korach, Kenneth S., Mauvais-Jarvis, Franck
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2009
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2750222/
https://ncbi.nlm.nih.gov/pubmed/19587358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-0257
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