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The role of rearrangement at the second immunoglobulin heavy chain locus in maintaining B-cell tolerance to DNA
In recently generated B6.56R anti-DNA autoantibody transgenic mice, it was noted that a substantial faction of the B-cells that had “avoided” DNA-reactivity had done so through the rearrangement and usage of the endogenous, non-targeted HC allele. This suggested that rearrangement at the second HC l...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2919372/ https://ncbi.nlm.nih.gov/pubmed/18490776 |
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