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DNA rearrangements in MPC-11 immunoglobulin heavy chain class-switch variants.
Immunoglobulin heavy chain class switching has been observed in vitro. In the IgG2b-producing MPC-11 mouse myeloma cell line, IgG2a-producing cells arise at a high frequency. In some cases, switch variants producing normal-sized (Mr 55,000) gamma 2a heavy chains have arisen spontaneously from a muta...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1982
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC346337/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6806822/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.79.9.3006 |
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