DNA rearrangements in MPC-11 immunoglobulin heavy chain class-switch variants.

Immunoglobulin heavy chain class switching has been observed in vitro. In the IgG2b-producing MPC-11 mouse myeloma cell line, IgG2a-producing cells arise at a high frequency. In some cases, switch variants producing normal-sized (Mr 55,000) gamma 2a heavy chains have arisen spontaneously from a muta...

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Bibliografiske detaljer
Main Authors: Eckhardt, L A, Tilley, S A, Lang, R B, Marcu, K B, Birshtein, B K
Format: Artigo
Sprog:Inglês
Udgivet: 1982
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC346337/
https://ncbi.nlm.nih.gov/pubmed/6806822
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