The Bcl-2 Homology Domain 3 Mimetic Gossypol Induces Both Beclin 1-dependent and Beclin 1-independent Cytoprotective Autophagy in Cancer Cells

Gossypol, a natural Bcl-2 homology domain 3 mimetic compound isolated from cottonseeds, is currently being evaluated in clinical trials. Here, we provide evidence that gossypol induces autophagy followed by apoptotic cell death in both the MCF-7 human breast adenocarcinoma and HeLa cell lines. We fi...

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Bibliografiska uppgifter
Huvudupphovsmän: Gao, Ping, Bauvy, Chantal, Souquère, Sylvie, Tonelli, Giovanni, Liu, Lei, Zhu, Yushan, Qiao, Zhenzhen, Bakula, Daniela, Proikas-Cezanne, Tassula, Pierron, Gérard, Codogno, Patrice, Chen, Quan, Mehrpour, Maryam
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2010
Ämnen:
Cell Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919121/
https://ncbi.nlm.nih.gov/pubmed/20529838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.118125
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