Defining regulatory and phosphoinositide-binding sites in the human WIPI-1 β-propeller responsible for autophagosomal membrane localization downstream of mTORC1 inhibition

BACKGROUND: Autophagy is a cytoprotective, lysosomal degradation system regulated upon induced phosphatidylinositol 3-phosphate (PtdIns(3)P) generation by phosphatidylinositol 3-kinase class III (PtdIns3KC3) downstream of mTORC1 inhibition. The human PtdIns(3)P-binding β-propeller protein WIPI-1 acc...

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Bibliografske podrobnosti
Main Authors: Gaugel, Anja, Bakula, Daniela, Hoffmann, Anneliese, Proikas-Cezanne, Tassula
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543385/
https://ncbi.nlm.nih.gov/pubmed/23088497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-2187-7-16
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