WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy

Autophagy is controlled by AMPK and mTOR, both of which associate with ULK1 and control the production of phosphatidylinositol 3-phosphate (PtdIns3P), a prerequisite for autophagosome formation. Here we report that WIPI3 and WIPI4 scaffold the signal control of autophagy upstream of PtdIns3P product...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Bakula, Daniela, Müller, Amelie J., Zuleger, Theresia, Takacs, Zsuzsanna, Franz-Wachtel, Mirita, Thost, Ann-Katrin, Brigger, Daniel, Tschan, Mario P., Frickey, Tancred, Robenek, Horst, Macek, Boris, Proikas-Cezanne, Tassula
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5460038/
https://ncbi.nlm.nih.gov/pubmed/28561066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15637
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