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Mechanism of Inhibition of Aliphatic Epoxide Carboxylation by the Coenzyme M Analog 2-Bromoethanesulfonate

The bacterial metabolism of epoxypropane formed from propylene oxidation uses the atypical cofactor coenzyme M (CoM, 2-mercaptoethanesulfonate) as the nucleophile for epoxide ring opening and as a carrier of intermediates that undergo dehydrogenation, reductive cleavage, and carboxylation to form ac...

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Библиографические подробности
Главные авторы: Boyd, Jeffrey M., Clark, Daniel D., Kofoed, Melissa A., Ensign, Scott A.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2010
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919086/
https://ncbi.nlm.nih.gov/pubmed/20551308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.144410
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