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Molecular basis for enantioselectivity in the (R)- and (S)-hydroxypropylthioethanesulfonate dehydrogenases, a unique pair of stereoselective short-chain dehydrogenases/reductases involved in aliphatic epoxide carboxylation

(R)- and (S)-2-hydroxypropyl-CoM (R-HPC and S-HPC) are produced as intermediates in bacterial propylene metabolism from the nucleophilic addition of coenzyme M to (R)- and (S)-epoxypropane, respectively. Two highly enantioselective dehydrogenases (R-HPCDH and S-HPCDH) belonging to the short-chain de...

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Bibliografiske detaljer
Main Authors: Sliwa, Dariusz A., Krishnakumar, Arathi M., Peters, John W., Ensign, Scott A.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858264/
https://ncbi.nlm.nih.gov/pubmed/20302306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100294m
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