Vitamin K 2,3-epoxide reductase: the basis for stereoselectivity of 4-hydroxycoumarin anticoagulant activity.

1. The administration of S-warfarin (1 mg kg-1 i.v.) to rats that were pre-loaded 48 h before with tracer doses (6 micrograms) of 14C-labelled R- or S-warfarin caused the plasma levels of these compounds to increase. This is due to the substitution of the microsomal (vitamin K 2,3-epoxide (K0) reduc...

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Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Thijssen, H. H., Baars, L. G., Vervoort-Peters, H. T.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1988
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1854203/
https://ncbi.nlm.nih.gov/pubmed/3207986
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