A new, but old, nucleoside analog: the first synthesis of 1-deaza-2′-deoxyguanosine and its properties as a nucleoside and as oligodeoxynucleotides

The first synthesis of 5-amino-3-(2′-deoxy-β-d-ribofuranosyl)imidazo[4,5-b]pyridin-7-one (1-deaza-2′-deoxyguanosine) is described. The compound was converted from the known AICA-deoxyriboside. The tautomeric structure of the base moiety was determined by theoretical calculation to be a hydroxyl form...

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Bibliografische gegevens

Gepubliceerd in:	Nucleic Acids Res
Hoofdauteurs:	Kojima, Naoshi, Inoue, Kaori, Nakajima-Shibata, Rina, Kawahara, Shun-ichi, Ohtsuka, Eiko
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Oxford University Press 2003
Onderwerpen:	Articles
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC291881/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14654693/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkh154
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