A new, but old, nucleoside analog: the first synthesis of 1-deaza-2′-deoxyguanosine and its properties as a nucleoside and as oligodeoxynucleotides
The first synthesis of 5-amino-3-(2′-deoxy-β-d-ribofuranosyl)imidazo[4,5-b]pyridin-7-one (1-deaza-2′-deoxyguanosine) is described. The compound was converted from the known AICA-deoxyriboside. The tautomeric structure of the base moiety was determined by theoretical calculation to be a hydroxyl form...
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| Pubblicato in: | Nucleic Acids Res |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2003
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC291881/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14654693/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkh154 |
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