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A new, but old, nucleoside analog: the first synthesis of 1-deaza-2′-deoxyguanosine and its properties as a nucleoside and as oligodeoxynucleotides

The first synthesis of 5-amino-3-(2′-deoxy-β-d-ribofuranosyl)imidazo[4,5-b]pyridin-7-one (1-deaza-2′-deoxyguanosine) is described. The compound was converted from the known AICA-deoxyriboside. The tautomeric structure of the base moiety was determined by theoretical calculation to be a hydroxyl form...

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Détails bibliographiques
Auteurs principaux: Kojima, Naoshi, Inoue, Kaori, Nakajima-Shibata, Rina, Kawahara, Shun-ichi, Ohtsuka, Eiko
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2003
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC291881/
https://ncbi.nlm.nih.gov/pubmed/14654693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh154
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