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Repair of a minimal DNA double-strand break by NHEJ requires DNA-PKcs and is controlled by the ATM/ATR checkpoint

Mammalian cells primarily rejoin DNA double-strand breaks (DSBs) by the non-homologous end-joining (NHEJ) pathway. The joining of the broken DNA ends appears directly without template and accuracy is ensured by the NHEJ factors that are under ATM/ATR regulated checkpoint control. In the current stud...

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Bibliografski detalji
Glavni autori: Kühne, Christian, Tjörnhammar, Marie-Louise, Pongor, Sándor, Banks, Lawrence, Simoncsits, András
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2003
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC291875/
https://ncbi.nlm.nih.gov/pubmed/14654698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg937
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