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Drug-Target Residence Time: Critical Information for Lead Optimization
Failure due to poor in vivo efficacy is a primary contributor to attrition during the development of new chemotherapeutics. Lead optimization programs that in their quest for efficacy focus solely on improving the affinity of drug-target binding are flawed, since this approach ignores the fluctuatio...
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| Główni autorzy: | , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2010
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2918722/ https://ncbi.nlm.nih.gov/pubmed/20663707 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2010.06.176 |
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