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Structure-Kinetic Relationships that Control the Residence Time of Drug-Target Complexes: Insights from Molecular Structure and Dynamics
Time-dependent target occupancy is a function of both the thermodynamics and kinetics of drug-target interactions. However, while the optimization of thermodynamic affinity through approaches such as structure-based drug design is now relatively straight forward, less is understood about the molecul...
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| Foilsithe in: | Curr Opin Chem Biol |
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| Main Authors: | , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2018
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6066427/ https://ncbi.nlm.nih.gov/pubmed/29986213 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2018.06.002 |
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