Ceftriaxone-induced up-regulation of cortical and striatal GLT1 in the R6/2 model of Huntington's disease

BACKGROUND: Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by cortico-striatal dysfunction and loss of glutamate uptake. At 7 weeks of age, R6/2 mice, which model an aggressive form of juvenile HD, show a glutamate-uptake deficit in striatum that can be rever...

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Bibliographic Details
Main Authors: Sari, Youssef, Prieto, Anne L, Barton, Scott J, Miller, Benjamin R, Rebec, George V
Format: Artigo
Language:Inglês
Published: BioMed Central 2010
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2918547/
https://ncbi.nlm.nih.gov/pubmed/20663216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-17-62
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