Up-regulation of GLT1 Expression Increases Glutamate Uptake and Attenuates the Huntington's Disease Phenotype in the R6/2 Mouse

The striatum, which processes cortical information for behavioral output, is a key target of Huntington's disease (HD), an autosomal dominant condition characterized by cognitive decline and progressive loss of motor control. Increasing evidence implicates deficient glutamate uptake caused by a...

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Bibliographic Details
Main Authors: Miller, Benjamin R., Dorner, Jenelle L., Shou, Minshan, Sari, Youssef, Barton, Scott J., Sengelaub, Dale R., Kennedy, Robert T., Rebec, George V.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2424273/
https://ncbi.nlm.nih.gov/pubmed/18353560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2008.02.004
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