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Using DNA Methylation Patterns to Infer Tumor Ancestry

BACKGROUND: Exactly how human tumors grow is uncertain because serial observations are impractical. One approach to reconstruct the histories of individual human cancers is to analyze the current genomic variation between its cells. The greater the variations, on average, the greater the time since...

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Bibliographic Details
Main Authors: Hong, You Jin, Marjoram, Paul, Shibata, Darryl, Siegmund, Kimberly D.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2918495/
https://ncbi.nlm.nih.gov/pubmed/20711251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012002
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