Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling

The cytokines IL-1 and TNF induce expression of a series of genes that regulate inflammation through activation of NF-κB signal transduction pathways. TAK1, a MAPKKK, is critical for both IL-1- and TNF-induced activation of the NF-κB pathway. TAB2, a TAK1-binding protein, is involved in IL-1-induced...

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Hauptverfasser: Ishitani, Tohru, Takaesu, Giichi, Ninomiya-Tsuji, Jun, Shibuya, Hiroshi, Gaynor, Richard B., Matsumoto, Kunihiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2003
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC291846/
https://ncbi.nlm.nih.gov/pubmed/14633987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg605
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