Osteocyte control of bone formation via sclerostin, a novel BMP antagonist

There is an unmet medical need for anabolic treatments to restore lost bone. Human genetic bone disorders provide insight into bone regulatory processes. Sclerosteosis is a disease typified by high bone mass due to the loss of SOST expression. Sclerostin, the SOST gene protein product, competed with...

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Detalhes bibliográficos
Main Authors: Winkler, David G., Sutherland, May Kung, Geoghegan, James C., Yu, Changpu, Hayes, Trenton, Skonier, John E., Shpektor, Diana, Jonas, Mechtild, Kovacevich, Brian R., Staehling-Hampton, Karen, Appleby, Mark, Brunkow, Mary E., Latham, John A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2003
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC291840/
https://ncbi.nlm.nih.gov/pubmed/14633986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg599
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