Sclerostin Is an Osteocyte-expressed Negative Regulator of Bone Formation, But Not a Classical BMP Antagonist

Sclerosteosis, a skeletal disorder characterized by high bone mass due to increased osteoblast activity, is caused by loss of the SOST gene product, sclerostin. The localization in bone and the mechanism of action of sclerostin are not yet known, but it has been hypothesized that it may act as a bon...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: van Bezooijen, Rutger L., Roelen, Bernard A.J., Visser, Annemieke, van der Wee-Pals, Lianne, de Wilt, Edwin, Karperien, Marcel, Hamersma, Herman, Papapoulos, Socrates E., ten Dijke, Peter, Löwik, Clemens W.G.M.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2004
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212719/
https://ncbi.nlm.nih.gov/pubmed/15024046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20031454
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki