Structural constraints on protein self-processing in l-aspartate-α-decarboxylase

Aspartate decarboxylase, which is translated as a pro-protein, undergoes intramolecular self-cleavage at Gly24–Ser25. We have determined the crystal structures of an unprocessed native precursor, in addition to Ala24 insertion, Ala26 insertion and Gly24→Ser, His11→Ala, Ser25→Ala, Ser25→Cys and Ser25...

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Main Authors: Schmitzberger, Florian, Kilkenny, Mairi L., Lobley, Carina M.C., Webb, Michael E., Vinkovic, Mladen, Matak-Vinkovic, Dijana, Witty, Michael, Chirgadze, Dimitri Y., Smith, Alison G., Abell, Chris, Blundell, Tom L.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2003
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC291833/
https://ncbi.nlm.nih.gov/pubmed/14633979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg575
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