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IAP-antagonists exhibit non-redundant modes of action through differential DIAP1 binding
The Drosophila inhibitor of apoptosis protein DIAP1 ensures cell viability by directly inhibiting caspases. In cells destined to die this IAP-mediated inhibition of caspases is overcome by IAP-antagonists. Genetic evidence indicates that IAP-antagonists are non-equivalent and function synergisticall...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2003
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC291812/ https://ncbi.nlm.nih.gov/pubmed/14657035 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg617 |
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