IAP-antagonists exhibit non-redundant modes of action through differential DIAP1 binding

The Drosophila inhibitor of apoptosis protein DIAP1 ensures cell viability by directly inhibiting caspases. In cells destined to die this IAP-mediated inhibition of caspases is overcome by IAP-antagonists. Genetic evidence indicates that IAP-antagonists are non-equivalent and function synergisticall...

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Veröffentlicht in:	EMBO J
Hauptverfasser:	Zachariou, Anna, Tenev, Tencho, Goyal, Lakshmi, Agapite, Julie, Steller, Hermann, Meier, Pascal
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 2003
Schlagworte:	Articles
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC291812/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14657035/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg617
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