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Activation of Checkpoint Kinase 2 by 3,3′-Diindolylmethane Is Required for Causing G(2)/M Cell Cycle Arrest in Human Ovarian Cancer Cells

We evaluated the effect of 3,3′-diindolylmethane (DIM) in ovarian cancer cells. DIM treatment inhibited the growth of SKOV-3, TOV-21G, and OVCAR-3 ovarian cancer cells in both a dose- and time-dependent manner with effective concentrations ranging from 40 to 100 μM. Growth-inhibitory effects of DIM...

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Sonraí Bibleagrafaíochta
Main Authors: Kandala, Prabodh K., Srivastava, Sanjay K.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Pharmacology and Experimental Therapeutics 2010
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2917853/
https://ncbi.nlm.nih.gov/pubmed/20444961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.063750
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