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Blocking Epidermal Growth Factor Receptor Activation by 3,3′-Diindolylmethane Suppresses Ovarian Tumor Growth In Vitro and In Vivo

Genetic alterations, including the overexpression of epidermal growth factor receptor (EGFR) (in approximately 70% of ovarian tumors), play a crucial role in the signal transduction pathways that regulate key cellular functions, such as cell survival and proliferation, and are responsible for compro...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kandala, Prabodh K., Wright, Stephen E., Srivastava, Sanjay K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310701/
https://ncbi.nlm.nih.gov/pubmed/22205686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.188706
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