Oral benzo[a]pyrene-induced cancer: two distinct types in different target organs depend on the mouse Cyp1 genotype

Benzo[a]pyrene (BaP) is a prototypical polycyclic aromatic hydrocarbon (PAH) found in combustion processes. Cytochrome P450 1A1 and 1B1 enzymes (CYP1A1, CYP1B1) can both detoxify PAHs and activate them to cancer-causing reactive intermediates. Following high dosage of oral BaP (125 mg/kg/day), ablat...

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Detalhes bibliográficos
Main Authors: Shi, Zhanquan, Dragin, Nadine, Miller, Marian L., Stringer, Keith F., Johansson, Elisabet, Chen, Jing, Uno, Shigeyuki, Gonzalez, Frank J., Rubio, Carlos A., Nebert, Daniel W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2917638/
https://ncbi.nlm.nih.gov/pubmed/20127859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.25222
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