Impaired T cell receptor activation in Interleukin-1 Receptor-associated Kinase-4-deficient patients

BACKGROUND: Interleukin-1 receptor associated kinase-4 (IRAK-4) is an effector of the Toll-like receptor and interleukin-1 receptor pathways, which plays a critical role in innate immune responses. The role of IRAK-4 in adaptive immune functions in humans is incompletely understood. OBJECTIVE: To ev...

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Main Authors: McDonald, Douglas R., Goldman, Frederick, Gomez-Duarte, Oscar D., Issekutz, Andrew C., Kumararatne, Dinakantha S., Doffinger, Rainer, Geha, Raif S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2917474/
https://ncbi.nlm.nih.gov/pubmed/20621347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2010.05.013
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