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Homodimerization of the human interleukin 4 receptor α chain induces Cɛ germline transcripts in B cells in the absence of the interleukin 2 receptor γ chain

The cytokines interleukin (IL)-4 and IL-13 play a critical role in inducing Cɛ germline transcripts and IgE isotype switching in human B cells. The IL-4 receptor (IL-4R) in B cells is composed of two chains, the IL-4-binding IL-4Rα chain, which is shared with the IL-13R, and the IL-2Rγ (γc) chain, w...

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Autori principali: Fujiwara, Hiroshi, Hanissian, Silva H., Tsytsykova, Alla, Geha, Raif S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences of the USA 1997
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC20872/
https://ncbi.nlm.nih.gov/pubmed/9159166
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