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3BP2 Deficiency Impairs the Response of B Cells, but Not T Cells, to Antigen Receptor Ligation
The adapter protein 3BP2 is expressed in lymphocytes; binds to Syk/ZAP-70, Vav, and phospholipase C-γ (PLC-γ); and is thought to be important for interleukin-2 gene transcription in T cells. To define the role of 3BP2 in lymphocyte development and function, we generated 3BP2-deficient mice. T-cell d...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1592712/ https://ncbi.nlm.nih.gov/pubmed/16809760 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00087-06 |
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