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3BP2 Deficiency Impairs the Response of B Cells, but Not T Cells, to Antigen Receptor Ligation

The adapter protein 3BP2 is expressed in lymphocytes; binds to Syk/ZAP-70, Vav, and phospholipase C-γ (PLC-γ); and is thought to be important for interleukin-2 gene transcription in T cells. To define the role of 3BP2 in lymphocyte development and function, we generated 3BP2-deficient mice. T-cell d...

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Bibliografiske detaljer
Main Authors: de la Fuente, Miguel A., Kumar, Lalit, Lu, Bao, Geha, Raif S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1592712/
https://ncbi.nlm.nih.gov/pubmed/16809760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00087-06
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