r84, a Novel Therapeutic Antibody against Mouse and Human VEGF with Potent Anti-Tumor Activity and Limited Toxicity Induction

Vascular endothelial growth factor (VEGF) is critical for physiological and pathological angiogenesis. Within the tumor microenvironment, VEGF functions as an endothelial cell survival factor, permeability factor, mitogen, and chemotactic agent. The majority of these functions are mediated by VEGF-i...

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Main Authors: Sullivan, Laura A., Carbon, Juliet G., Roland, Christina L., Toombs, Jason E., Nyquist-Andersen, Mari, Kavlie, Anita, Schlunegger, Kyle, Richardson, James A., Brekken, Rolf A.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2917360/
https://ncbi.nlm.nih.gov/pubmed/20700512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012031
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