r84, a Novel Therapeutic Antibody against Mouse and Human VEGF with Potent Anti-Tumor Activity and Limited Toxicity Induction

Vascular endothelial growth factor (VEGF) is critical for physiological and pathological angiogenesis. Within the tumor microenvironment, VEGF functions as an endothelial cell survival factor, permeability factor, mitogen, and chemotactic agent. The majority of these functions are mediated by VEGF-i...

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Detalhes bibliográficos
Main Authors: Sullivan, Laura A., Carbon, Juliet G., Roland, Christina L., Toombs, Jason E., Nyquist-Andersen, Mari, Kavlie, Anita, Schlunegger, Kyle, Richardson, James A., Brekken, Rolf A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2917360/
https://ncbi.nlm.nih.gov/pubmed/20700512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012031
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