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Suppression of Indued Pluripotent Stem Cell Generation by the p53-p21 Pathway
Induced pluripotent stem (iPS) cells can be generated from somatic cells by introduction of Oct3/4, Sox2, Klf4 and c-Myc, in mouse1-4 and human5-8. Efficiency of this process, however, is low9. Pluripotency can be induced without c-Myc, but with even lower efficiency10,11. A p53 siRNA was recently s...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2917235/ https://ncbi.nlm.nih.gov/pubmed/19668191 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08235 |
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