RNAi Screening Implicates a SKN-1–Dependent Transcriptional Response in Stress Resistance and Longevity Deriving from Translation Inhibition

Caenorhabditis elegans SKN-1 (ortholog of mammalian Nrf1/2/3) is critical for oxidative stress resistance and promotes longevity under reduced insulin/IGF-1–like signaling (IIS), dietary restriction (DR), and normal conditions. SKN-1 inducibly activates genes involved in detoxification, protein home...

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Autors principals: Wang, Jinling, Robida-Stubbs, Stacey, Tullet, Jennifer M. A., Rual, Jean-François, Vidal, Marc, Blackwell, T. Keith
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916858/
https://ncbi.nlm.nih.gov/pubmed/20700440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001048
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