Direct inhibition of the longevity promoting factor SKN-1 by Insulin-like signaling in C. elegans

Insulin/IGF-1-like signaling (IIS) is central to growth and metabolism, and has a conserved role in aging. In C. elegans, reductions in IIS increase stress resistance and longevity, effects that require the IIS-inhibited FOXO protein DAF-16. The C. elegans transcription factor SKN-1 also defends aga...

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Main Authors: Tullet, Jennifer M. A., Hertweck, Maren, Hyung An, Jae, Baker, Joseph, Hwang, Ji Yun, Liu, Shu, Oliveira, Riva P., Baumeister, Ralf, Blackwell, T. Keith
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2367249/
https://ncbi.nlm.nih.gov/pubmed/18358814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.01.030
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